"One of the most
promising treatments in this category is a drug called CM-AT made by a startup
called Curemark. Dr. Joan Fallon, the company's founder and CEO, observed that
many autistics show a strong preference for foods high in carbohydrates and low
in protein. A diagnostic test revealed that some autistic children lack enzymes
that digest protein. As a result, these children produce fewer of the essential
amino acids that are the building blocks for brain development and
neuroreception. Fallon believes this deficiency is linked to the most severe
symptoms of autism, and she says an early observational study of CM-AT, an
orally ingested powder that delivers protein-digesting protease, showed
"significant improvements." Curemark is enrolling patients in phase
III clinical trials at 10 to 12 site the largest autism trial to date."
January 25, 2010
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